Thyrin Tablet 50mcg

Indication:

1. Hypothyroidism - Primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) hypothyroidism and subclinical

hypothyroidism.

2. Pituitary TSH Suppression

Dosage & Administration:

Dosing must be individualized and adjustments made based on periodic assessment of the patient’s clinical response and laboratory

parameters.

a) Adult Dosage

Initial starting dose: 25-50 mcg/day, with gradual increments in dose at 6-8weekintervals, as needed. The dose is generally

adjusted in 12.5-25 mcg increments until the patient with primary hypothyroidism is clinically euthyroid and the serum TSH has

normalized.

In patients with severe hypothyroidism: 12.5-25 mcg/day with gradual increment of 25 mcg/ day every 2-4 weeks.

In patients with secondary (pituitary) or tertiary (hypothalamic) hypothyroidism: The dose should be titrated until the patient is

clinically euthyroid and the serum free- T4 level is restored to the upper half of the normal range.

For patients older than 50 years or for patients under 50 years of age with underlying cardiac disease: 1.7 mcg/kg/day.

b) Pediatric Dosage

Newborns

The recommended starting dose is 10-15 mcg/kg/day. In infants with very low (< 5 mcg/dL) or undetectable serumT4 concentrations,

the recommended initial starting dose is 50 mcg/day.

Infants and Children

Initial dose is 25 mcg/day with increments of 25 mcg every 2-4 weeks until the desired effect is achieved.

Preparation:

Thyrin®50 Tablet: Box containing 90 tablets.

Thyrin® 25 Tablet: Box containing 90 tablets.