Dicaltrol Capsule 0.25mcg

DICALTROL

Calcitriol BP

Composition : Each dicaltrol soft gelatin capsule contains calcitriol BP 0.25mcg.

Indications : Predialysis patients : Dicaltrol is indicated in the management of secondary hyperparathyroidism and resultant

metabolic bone disease in patients with moderate to severe chronic renal failure not yet on dialysis. In children, the creatinine

clearance value must be corrected for a surface area of 1.73 square meters..

Dosage & Administration : Predialysis Patients : The recommended initial dosage of Dicaltrol is 0.25 mcg/day in adults and

pediatric patients 3 years of age and older. This dosage may be increased if necessary to 0.5 mcg/day.

Dialysis Patients : The recommended initial dose of Dicaltrol is 0.25 mcg/day. If a satisfactory response in the biochemical

parameters and clinical manifestations of the disease state is not observed, dosage may be increased by 0.25 mcg/day at 4 to 8

week intervals. During this titration period, serum calcium levels should be obtained at least twice weekly, and if hypercalcaemia

is noted, the drug should be immediately discontinued until normocalcaemia ensues. Patients with normal or only slightly reduced

serum calcium levels may respond to Dicaltrol doses of 0.25 mcg every other day. Most patients undergoing hemodialysis respond to

doses between 0.5 and 1mcg/day.

Hypoparathyroidism : The recommended initial dosage of Dicaltrol is 0.25 mcg/day given in the morning. If a satisfactory response

in the biochemical parameters and clinical manifestations of the disease is not observed, the dose may be increased at 2 to 4 week

intervals. During the dosage titration period, serum calcium levels should be obtained at least twice weekly and if hypercalcaemia

is noted, Dicaltrol should be immediately discontinued until normocalceamia ensues. Careful consideration should also be given to

lowering the dietary calcium intake. Most adult patients and pediatric patients age 6 years and older have responded to dosages in

the range of 0.5 mcg to 2 mcg daily. Pediatric patients in the 1 to 5 year age group with hypoparathyroidism have usually been

given 0.25mcg to 0.75mcg daily. The number of treated patients with

pseudohypoparathyroidism less than 6 years of age is too small to make dosage recommendations.

Postmenopausal Osteoporosis : The recommended dose for Dicaltrol is 0.25 mcg twice daily. Serum calcium and creatinine levels

should bedetermined at 4 weeks, 3 and 6 months and at 6 monthly intervals there after.

Use in pregnancy and lactation : Use in pregnancy and lactation Dicaltrol should be given only when the potential benefit has been

weighed against the possible hazard to the fetus. Mothers should not breast-feed while taking Dicaltrol.

Packing : Each box contains 60's capsule in blister pack.

Prescribing Description

[https://www.drug-international.com/uploads/product_pdf/1643011474Dicaltrol BOOK DTYLE INSERT.pdf]